I guess its possible but ZZ seems like it would be the hardest method to achieve full CN with, and the benefits of it probably wouldn't out weigh the enormity of the task of learning it/relearning the cube and adjusting to strange EOline. I'm not really sure how CN would help much with ZZ.
Also, because ZZ is so <R,U,L> intensive you should already be using your left hand anyway. Oh, and also, cube rotations are something to be avoided in almost any method; although, I still rotate too much.