I'd say that Ortega can be almost as fast as CLL alone. The way to go for fast 2x2 cubers is to learn CLL, full EG and even some additional cases like part of TCLL, etc. So, if you don't plan on learning EG maybe the extra effort of learning the full CLL (like 42 algs) if not worth it. What Ortega loses by being a 3-look method against CLL (wich we can say is a 2-look method) it takes back with added flexibility in building your 1st face, which for CLL has to be a layer.
You can argue that CLL can be one-looked but, to be honest, if you are good enough at inspection so as to one-look every solve with CLL you can, even more easily, predict your OLL with Ortega and probably even your PBL too, as Ortega faces are on average less moves than a CLL layer. And the time you save on learning algs you can devote to optimizing your prediction, face building...
I average around 5.5 with Ortega and I don't think I could get much more than 0.5 seconds faster with CLL if at all.