cuBerBruce
Veteran
You should find that any insertion made within the part of the solution that you have already checked will still work. It will not matter if the premoves are before the scramble, or at the end of your solution, just as long as those moves are still within the sequence. Some (or all) of the unsolved cubies will likely be different colours, however their position within that part of the solution will be the same.
I think you missed Cubenovice's point.
In the example, if you use the scramble with premoves, you will find you need to cycle (ULF,BLU,RDB,DFL,RFD) at the end of the skeleton. If instead, you don't apply the premoves before the scramble, but apply them after the skeleton moves, you find you need to cycle (UFR,BUR,BRD,DFL,LUB).
If you were to put stickies on the cube to look for insertions to solve (ULF,BLU,RDB,DFL,RFD), but then apply the scramble without premoves, the insertions you find will be for cycling the wrong pieces. You will be cycling(ULF,BLU,RDB,DFL,RFD) when you need to be cycling (UFR,BUR,BRD,DFL,LUB).