@pglewis, another vote for no more restickering big cubes!!!
I have 2 cubes in both stickerless and stickered (Weilong V2 and Valk 3), and from that tiny sample I'd say there's 3 factors in play: recognition, feel, and plastic quality.
Recog first - with stickerless cubes you can't choose your preferred shades, but contrast isn't an issue. There used to be posts on here, in the Dayan days, about the different contrast between stickers and plastic on black/white/undyed plastic. Again, not an issue on stickerless cubes. I think some will prefer stickers, some stickerless, in the same way as some can solve on a purple cube with silver stickers, others can't!
In terms of feel, I mean the physical feeling of the stickers on the cubies, rather than the feel when turning. Stickered cubes are more tactile, and perhaps easier to grip. Stickerless feel smoother and, in an odd way, smaller. I particularly get this with my Valks, when going back to stickered from stickerless (main), the cube feels less small, and there's an odd (but not unpleasant) feeling from the stickers under my fingertips.
Thirdly, plastic quality. We all know that dying plastic affects it in many ways. Natural plastic Dayan cubes were popular for this reason (among others). It affects the sensation of the cube when turning, as plastic on plastic friction will be different. For me, stickerless cubes feel like the plastic is slightly thinner. This may be a placebo caused by the lack of a physical layer of vinyl, it may be just me, or it may be an actual thing!! For 4x4+, I think stickerless cubes feel slightly scratchy "out of the box", but breaking in seems to have more of an effect on them than stickered, and they become smoother as you rack up the solves. On this subject, I'd imagine the quantity of lube required would also vary, but that's a whole other can of worms...
So for me there are at least 3 significant differences. Whether stickered or stickerless is better will be a subjective choice on the part of each cyber.
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