At Exeter Open 2016, I struggled so badly with the second 4BLD scramble that I threw the solve away. However, everyone else who had a success got it on that scramble! So I reconstructed to see why I found it so difficult.
B R2 U2 F U2 F L2 D2 F D B' D' F' D' R2 D L R' F' D2 Fw2 R' Uw2 D Rw2 Uw2 R' L2 D Fw2 B2 U L' Fw' L F' D U F' Uw' Fw L2 Uw Rw2 U' R2 z' y'
Using the orientation I chose in comp (three yellows on top, white at Ubr) I couldn't do it at home either. I had to write down the wing memo to find my mistake. It was 28 targets, 5 breaks. Awful. So I tried it with the white at Ufr. Wing memo was now easy - 24 with 1 break. (I guessed that's the orientation the others would most likely have chosen as it gave more solved centres overall; I had traded two side centres for not having to solve any U-face centres

).
That taught me something I didn't realize about 4BLD. Because centres are not fixed, wing and corner cycles depend on orientation, unlike 3BLD. (It should have been obvious to me because there are simple examples, like two wings swapped in place no longer being an isolated 2-cycle if you change the orientation.)
So now I am curious whether any experienced 4BLDers use this in choosing an orientation? I have always looked at centres only, but it seems just as valid to take into account solved wings or corners, corner twists, or even avoiding obvious 2-cycles on wings or corners.
And a related question - can orientation affect wing or corner parity? My thinking is no, because a quarter rotation would be equivalent to two quarter moves on opposite faces... but I might be wrong.