I'm surprised there isn't a lot of discussion on this so I'm making a poll, a quick rundown for all the methods in case you don't know. Yau: Solve two adjacent centers, make 3 cross edges and attach them to the center, make the rest of the centers, solve the last cross edge, edge pairing, solve like 3x3. Hoya: Solve all centers except for front and top, inert cross edges to solve cross, solve last two centers, edge pairing, solve like 3x3. Redux: Solve all centers, edge pairing, solve like a 3x3. F3L: (Note I'm basing this off of cube masters method there are some other F3L methods out there) Solve bottom center (Must be cross color), join cross edges and vertical center bars to simultaneously solve cross and centers, edge pairing, solve like a 3x3.
I personally use Hoya for its freedom with the first four centers and not having to solve the last cross edge after finishing centers.