I'm gonna be completely honest with you...I have no idea what will happen for sure. Although I have a good prediction of what I think would happen. I don't think it would have much effect on the cube's performance, but it might make that side scratchy and kind of crunchy. And worst case scenario (keep in mind that this is very unlikely to happen) is that the screw erodes away at the center piece, causing plastic dust to accumulate in the piece and go everywhere, and after about 2,000-5,000 solves, the screw would actually erode all the way through the center piece and essentially push it off. But the chances of this happening are about 1 in 100,000. It shouldn't have much effect. But if it does strip away at the center piece, then you might want to order a replacement part from thecubicle.us. If anything else happens you're not sure about, then feel free to contact me.