I think there's a few reasons:
1. It was one of the first distance-20 positions discovered, and set the lower bound for God's Number.
2. It's a cool looking pattern.
3. Superflip+Fourspot (Fourspot looks like this: M2 E M2 E') is the only known distance-26 position in QTM (where half turns count as two moves), so Superflip has significance in this sense.
4. It's more symbolic than any of the other distance-20 positions, because it's not just a random looking scramble. It's sort of like finding some sort of algebraic relationship (like 22/7) for pi, which would be mind blowing. It's sort of like if a random scramble is a transcendental number, Superflip is the algebraic number in the sequence. Not sure if this makes sense, but it make sense to me.
These are just what I think, but I really don't know why it is so difficult mathematically.