Yes, I have used it for nxnxn parity state analysis.
This paper shows usage of algebra, trigonometry, calculus, and some discrete math.
Although I develop a (two variable) quadratic expression in that paper, I later used the actual quadratic formula itself (not in that paper, but in a book I intend to publish within the next few years) to solve an equation where the "numbers" are actually variables themselves. Probably a little over your head right now due to the context for which it is used!
TLDR. Yes, but in a very niche part of "nxnxn Rubik's Cube theory" that would be more trouble than it's worth to understand why it's being used there. (At least from someone who just wants to see "applications" of high school math in cubing.)