My Megaminx color scheme has yellow opposite white, tan in place of yellow and grey in the place of tan. I did it coz white is opposite to yellow on 3x3 and it was my last layer color (before I became CN though).
In most beginners tutorial the targets on R and L face are setup using B moves. But in more advanced M2, you might need to solve it using rotations. While using DF as the buffer, you get better commutators and can use better fingertricks.
To set up to UR piece, you use R U R' U'...